David Borchelt

Acetylation mimetic and null mutations within the filament core of P301L tau have varied effects on susceptibility to seeding and aggregation

This study examines how acetylation and phosphorylation mutations affect tau aggregation and seeding in Alzheimer's and PSP models.

Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity

This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.

A combinatorial approach to ALS therapies in the PrP.TDP43-315 model of ALS; complications and tribulations

The paper tests drug combinations in a TDP43-ALS mouse model to extend lifespan but finds no substantial lifespan extension despite dietary interventions.

Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease

The paper identifies a conserved Aβ amyloid 'responsome' in human and mouse AD brains, showing how amyloid scaffolds proteins involved in disease pathology.

Human APOE allelic variants suppress the formation of diffuse and fibrillar Aβ deposits relative to mouse Apoe in transgenic mouse models of Alzheimer amyloidosis

This study shows human APOE variants reduce both diffuse and fibrillar Aβ deposits in transgenic mouse models compared to mouse Apoe, with APOE3 more effective than APOE4 in some contexts.

Assessment of levamisole HCl and thymosin α1 in two mouse models of amyotrophic lateral sclerosis

This study evaluates the effects of levamisole HCl and thymosin α1 in two mouse ALS models, finding no significant survival extension but potential benefits in reducing ubiquitin load.

ALS-linked SOD1 Mutants Enhance Outgrowth, Branching, and the Formation of Actin-Based Structures in Adult Motor Neurons

The paper shows that mutant SOD1 increases axonal outgrowth, dendritic branching, and actin-based structures in adult motor neurons from ALS mouse models, suggesting a potential therapeutic target.