Author

Zachary S. Gardner

University of Minnesota, Duluth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 2 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Conor T. RonayneiD· 3 shared Venkatram R. MereddyiD· 3 shared Anuj Kumar SinghiD· 1 shared Greeshma P. Kumpati· 1 shared Jon N. RumbleyiD· 1 shared Mathew Jacob· 1 shared Shirisha JonnalagaddaiD· 1 shared Sravan K. JonnalagaddaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 20 mutual co-author links

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3 shared papersCancer Biology

Conor T. RonayneORCID

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3 papers

Recent·Most cited

Synthesis and biological evaluation of glutathione-responsive 2-alkoxycarbonyl allyl niclosamide prodrugs as anticancer agents

Anuj Kumar Singh, Zachary S. Gardner, Greeshma P. Kumpati, Mathew Jacob, Conor T. Ronayne, Venkatram R. Mereddy

This study synthesizes and evaluates glutathione-responsive niclosamide prodrugs as anticancer agents, showing reduced toxicity and tumor growth inhibition in mice.

Current Medicinal Chemistry · Aug 25, 2026Peer-reviewedPharmacology & Toxicology

Synthesis and evaluation of novel N,N-dialkylcinnamic acid-based mitochondrial pyruvate carrier inhibitors: Biosynthetic and energetic lethality of targeting metabolic plasticity in cancer

Sravan K. Jonnalagadda, Conor T. Ronayne, Shirisha Jonnalagadda, Zachary S. Gardner, Venkatram R. Mereddy

The paper synthesizes and evaluates novel mitochondrial pyruvate carrier inhibitors for cancer treatment, showing activity in vitro and metabolic plasticity inhibition.

bioRxiv · Jan 13, 2026 · PreprintCancer Biology

Development of fluoro-7-aminocarboxycoumarin-based mitochondrial pyruvate carrier inhibitors as anticancer agents

Tanner J. Schumacher, Zachary S. Gardner, Jon N. Rumbley, Conor T. Ronayne, Venkatram R. Mereddy

The paper develops novel fluoro-substituted aminocarboxycoumarin derivatives as mitochondrial pyruvate carrier inhibitors with anticancer potential.

Journal of Biological Chemistry · Jul 16, 2025Peer-reviewedCancer Biology