Synthesis and evaluation of novel N,N-dialkylcinnamic acid-based mitochondrial pyruvate carrier inhibitors: Biosynthetic and energetic lethality of targeting metabolic plasticity in cancer
Sravan K. Jonnalagadda, Conor T. Ronayne, Shirisha Jonnalagadda, Zachary S. Gardner, Venkatram R. Mereddy
The paper synthesizes and evaluates novel mitochondrial pyruvate carrier inhibitors for cancer treatment, showing activity in vitro and metabolic plasticity inhibition.
bioRxiv · Jan 13, 2026 · PreprintCancer Biology