Highly conserved brain vascular receptor ALPL mediates transport of engineered viral vectors across the blood-brain barrier
Tyler Chistopher Moyer, Brett A. Hoffman, Weitong Chen, Ishan S. Shah, Xiao‐Qin Ren, Tatiana M. Knox, Jiachen Liu, Wei Wang, Jiangyu Li, Hamza Khalid, Anupriya S. Kulkarni, Munachiso Egbuchulam, Joseph Clement, Alexis Bloedel, Matthew Child, , Mathieu E. Nonnenmacher
This study identifies VCAP-102, an AAV9 variant with enhanced brain delivery across species, mediated by ALPL receptor interaction.
bioRxiv · Mar 12, 2024 · PreprintNeuroscience