Author

Weitong Chen

Rice UniversityORCID 0000-0001-9011-6186Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alexander Kutchin· 1 shared Alexis Bloedel· 1 shared Ambreen Sayed-Zahid· 1 shared Amy Jo JohnsoniD· 1 shared Anupriya S. KulkarniiD· 1 shared Brett A. HoffmaniD· 1 shared Charlotte Hiu-Yan ChungiD· 1 shared Damien Maura· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Alexander Kutchin

Mutual co-authors in cluster

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintMar 12, 2024

Highly conserved brain vascular receptor ALPL mediates transport of engineered viral vectors across the blood-brain barrier

Tyler Chistopher Moyer, Brett A. Hoffman, Weitong Chen…·Mathieu E. Nonnenmacher

This study identifies VCAP-102, an AAV9 variant with enhanced brain delivery across species, mediated by ALPL receptor interaction.

13 citations

mousenon-human primate

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJun 15, 2021

Machine Learning Identification of Capsid Mutations to Improve AAV Production Fitness

Georgios Mikos, Weitong Chen, Junghae Suh

This study uses machine learning to predict AAV capsid mutations that improve production fitness, finding threefold more effective mutations than random.

5 citations

protein structuremachine learning (classical)

𝕏 PostBluesky