Lateral hypothalamic input engages a disinhibitory microcircuit in the dorsal raphe to promote behavior activation
Renata Sadretdinova, Arturo Marroquin Rivera, Zakaria Benmamma, Maryse Pinel, Vincent Émond, Chenqi Zhao, Frédéric Calon, Benoît Labonté, Christophe D. Proulx
The paper identifies a disinhibitory pathway from the lateral hypothalamus to the dorsal raphe nucleus that promotes behavioral activation by reducing local inhibition of serotonergic neurons.
bioRxiv · Feb 27, 2026 · PreprintNeuroscience