Frédéric Calon

Natural Microbial Enrichment Modulates Microglial States and Transcriptional Programs Relevant to Alzheimer's Disease

This study shows that introducing natural microbial environments to mice alters microglial states and transcriptional programs, increasing similarity to human Alzheimer's disease profiles.

WDR44 drives de novo α-synuclein aggregation at the lysosomal membrane and promotes neuronal dysfunction in Parkinson's Disease

This study identifies WDR44 as a driver of de novo α-synuclein aggregation at the lysosomal membrane, linking early aggregation events to neuronal dysfunction in Parkinson's Disease.

Lateral hypothalamic input engages a disinhibitory microcircuit in the dorsal raphe to promote behavior activation

The paper identifies a disinhibitory pathway from the lateral hypothalamus to the dorsal raphe nucleus that promotes behavioral activation by reducing local inhibition of serotonergic neurons.

Parkinson's disease risk factors are expressed at brain barriers.

This study identifies Parkinson's disease risk genes expressed at brain barriers and shows poor transcript-protein correlation and low interspecies conservation.

Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer's disease

This study identifies altered firing patterns in VIP interneurons and early dysfunction in CA1 hippocampal circuits in 3xTg-AD mice, suggesting a potential mechanism for AD pathology.

Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia

The paper shows sauna-like conditions and menthol treatment reduce tau phosphorylation through mild hyperthermia in mice and neuron-like cells.

Cerebrovascular insulin receptors are defective in Alzheimer's disease

The paper shows that insulin receptors in microvessels at the blood-brain barrier are defective in Alzheimer's disease, contributing to brain insulin resistance and cognitive impairment.

The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular network

This study shows that CD2AP loss in brain endothelial cells impairs vascular function and memory in AD models, suggesting therapeutic targeting of CD2AP pathways.