Benoît Labonté

The paper investigates sex differences in epigenetic changes linked to chronic pain-induced depression in mice, finding distinct genomic loci but shared regulatory features and gene modules across sexes.

The paper identifies sex-specific spatial reorganization of mPFC-VTA neuronal loops under stress using viral tracing and spatial clustering.

The paper identifies a disinhibitory pathway from the lateral hypothalamus to the dorsal raphe nucleus that promotes behavioral activation by reducing local inhibition of serotonergic neurons.

This study identifies sex-specific transcriptional changes in mPFC-NAc pathway neurons under chronic stress, revealing Xlr4b as a stress susceptibility driver in males.

The paper introduces a non-invasive tailtag system using ArUco markers to track multiple mice in social groups over seven days without performance degradation.

PrecisionTrack provides a platform for automated long-term social behavior analysis in naturalized environments, enabling real-time tracking and social interaction inference in large animal groups.

This study identifies sex-specific gene modules linked to MDD symptom domains in brain regions, revealing distinct transcriptional signatures in males and females.

The paper identifies FEDORA, a lncRNA with sex- and cell-type-specific effects on depression in females.

This study investigates how chronic stress affects male and female mice's cortico-accumbal and cortico-tegmental pathways, revealing sex-specific functional, morphological, and transcriptional changes.

This study investigates how chronic social defeat stress affects dopaminergic pathways in male and female mice, revealing sex-specific molecular changes in the VTA, NAc, and mPFC.

This study shows that chronic social stress affects retinal ERG responses differently in male and female mice, suggesting retinal activity as a potential biomarker for stress response.

The paper identifies epigenetic changes in mice exposed to chronic social defeat stress, showing convergence with human neuroticism pathways.

The paper compares RNAseq methods for analyzing medium spiny neurons in the nucleus accumbens, finding that nuclear-FACS-seq identifies more differentially expressed genes and GWAS hits than other methods.

The paper identifies Zfp189 as a key driver of a transcriptional network promoting stress resilience in prefrontal cortex neurons through CREB regulation.