Pharmacologic inhibition of OLIG2 by CT-179 disrupts mitotic progression and enhances standard-of-care chemoradiotherapy in glioblastoma
Sameer A. Greenall, Shengnan C Chen, Gordon Alton, Graham Beaton, Reghan Boelter, Teresa Venezia Bowman, Ivan Babić, Zara C. Bruce, Daniel J. Garama, Rajesh Mukthavaram, Fábio C. Tucci, Ravula Satheesh Babu, Ambrosio Lopez, Susan K. Knowles, Gregory Stein, , Rohan G. T. Lowe
This study shows that CT-179, an OLIG2 inhibitor, reduces glioblastoma growth and enhances chemoradiotherapy efficacy in preclinical models.
bioRxiv · Oct 20, 2026 · PreprintCancer Biology