Novel Mechanism of Inflammatory Activation by Ebola Virus Matrix Protein Linked to the Ebolavirus Virulence
Satoko Yamaoka, Zeineb Mhamdi, Lin Wang, Vaille A. Swenson, Kristin L. McNally, Shao‐Chia Lu, Reema Singh, Stephanie L. Saundh, Brady N. Zell, Sonja M. Best, Michael A. Barry, Angela L. Rasmussen, Hideki Ebihara
This study identifies VP40 as a key virulence factor in Ebola virus that drives pro-inflammatory responses through NF-κB activation in non-immune cells, independent of TLR4.
Proceedings of the National Academy of Sciences · Dec 29, 2025Peer-reviewedMicrobiology