Michael A. Barry

Mapping First In Vivo Ebolavirus Infection Events

This study uses EBOV trVLPs to map first in vivo infection events in mice, showing direct infection of T cells, monocytes, dendritic cells, and Langerhans cells.

mRNA Therapy for Alport Syndrome

This paper demonstrates that mRNA therapy can reduce proteinuria and blood urea nitrogen in a mouse model of Alport syndrome by delivering collagen IV proteins via lipid nanoparticles.

Novel Mechanism of Inflammatory Activation by Ebola Virus Matrix Protein Linked to the Ebolavirus Virulence

This study identifies VP40 as a key virulence factor in Ebola virus that drives pro-inflammatory responses through NF-κB activation in non-immune cells, independent of TLR4.

Induced Proteinuria Enhances Adeno-Associated Virus Transduction of Renal Tubule Epithelial Cells After Intravenous Administration

The paper shows that inducing proteinuria enhances viral vector transduction of renal tubule epithelial cells after intravenous administration.

Impact of Propionic Acidemia on Brain Astrocytes

This study investigates the impact of propionic acidemia on astrocytes, finding minimal alterations in both in vitro and in vivo models, suggesting astrocytes may not be a primary target for therapy.

Expanding The CRISPR Toolbox With Mad7 In Zebrafish And Human Cells

This paper characterizes ErCas12a, a new CRISPR/Cas system, showing it enables efficient DNA repair and gene integration in zebrafish and human cells.