Large-scale genome- and phenome-wide analyses reveal the genetic architecture, pathophysiology and comorbidity of restless legs syndrome
Xiaoxi Jing, Zi Wang, Jacob Williams, Junpeng Zhao, Kaiyan Ma, Xiaoxuan Fu, Jianxun Ren, Ouyang Chen, Hongen Kang, Jiecong Lin, Zeqi Yan, Jiaxiang Zhang, Xicheng Zhang, Yafei Zhu, Hesheng Liu, , Yajie Zhao
This study identifies 15 novel RLS-associated loci and links them to neurodevelopmental programs, while revealing over 100 comorbidities and brain structural associations through genome- and phenome-wide analyses.
medRxiv · May 22, 2026 · PreprintGenetic & Genomic Medicine