Haitao Zhang

The Hippo Signaling Pathway Regulates Corneal Endothelial Regeneration

This study identifies the Hippo signaling pathway's role in regulating corneal endothelial regeneration across species, showing that YAP activation promotes wound healing and suggesting it as a therapeutic target.

SynPROTAC: synthesizable PROTACs design through synthesis constrained generative model and reinforcement learning

SynPROTAC generates novel PROTAC molecules with feasible synthetic routes and favorable properties using a synthesis-constrained generative model and reinforcement learning.

Multi-timescale motor circuit dynamics underlies adaptive and efficient exploratory behavior

The paper identifies multi-timescale motor dynamics in C. elegans head exploratory behavior using variational mode decomposition and neuronal ablation, revealing roles of specific motor neurons in locomotion.

Large-scale genome- and phenome-wide analyses reveal the genetic architecture, pathophysiology and comorbidity of restless legs syndrome

This study identifies 15 novel RLS-associated loci and links them to neurodevelopmental programs, while revealing over 100 comorbidities and brain structural associations through genome- and phenome-wide analyses.

EpiReasoner: An Integrated Artificial Intelligence Framework for Phenotype-to-Genotype Reasoning in Plant Epidermal Development

EpiReasoner integrates AI for phenotype-to-genotype reasoning in plant epidermal development, identifying a major QTL for stomatal density in tomatoes.

cfMIND: A read-level methylation framework for accurate non- invasive disease detection using cell-free DNA

cfMIND improves non-invasive disease detection by analyzing read-level methylation signals from cell-free DNA, achieving high accuracy even at low sequencing depth and across diverse cancers.

Inhibition of CKAMP44 attenuated seizure activity via protein phosphatase 3 regulatory subunit B-mediated GluA1 phosphorylation and synaptic transmission

This study shows that inhibiting CKAMP44 reduces seizure activity in TLE by increasing GluA1 phosphorylation and synaptic transmission through PPP3r2 regulation.

Pneumo-Typer: integrated genomic surveillance tool for capsule genotype, serotype and sequence type in Streptococcus pneumoniae informs vaccine strategies

Pneumo-Typer identifies capsule genotype variations in Streptococcus pneumoniae genomes, revealing CapT diversity and informing vaccine strategies.

In Vivo Proximity Labeling Identifies a New Function for the Lifespan and Autophagy-regulating Kinase Pef1, an Ortholog of Human Cdk5

The paper uses proximity labeling to identify Pef1's role in DNA damage response and autophagy-related processes in S. pombe.