Jacob Williams

This paper identifies 116 risk loci for melanoma through GWAS, links susceptibility to immunity and Wnt signaling, and develops a PRS improving risk prediction.

This study analyzes breast cancer GWAS across multiple ancestries, finding similar heritability and genetic correlations, and identifies shared regulatory and cellular contexts.

This study integrates polygenic risk scores and proteomic risk scores to improve prediction of complex traits across diverse populations.

MetaSTAARlite is a tool for rare variant meta-analysis using summary statistics from biobank-scale whole-genome sequencing data, showing linear scaling and concordance with pooled analysis.

This study identifies 15 novel RLS-associated loci and links them to neurodevelopmental programs, while revealing over 100 comorbidities and brain structural associations through genome- and phenome-wide analyses.

The paper develops and validates multi-ancestry polygenic risk scores for LUAD in East Asian never-smokers, showing improved risk prediction compared to East Asian-only models.

This study identifies a unique mutational signature, SBS87, in testicular germ cell tumors (TGCTs) that resembles thiopurine-induced DNA damage and is associated with tumor latency and telomere elongation.