Chromosome territory reorganization through artificial chromosome fusion is negligible to cell fate determination and mouse development.
Yuang Wang, Zhen Qu, Yi Fang, Yulong Chen, Jiayin Peng, Jiawen Song, Jinsong Li, Jiantao Shi, Jin‐Qiu Zhou, Yun Zhao
This study fuses chromosomes 15 and 17 in mouse haploid embryonic stem cells and finds minimal impact on gene expression, pluripotency, and mouse development.
bioRxiv · Oct 9, 2022 · PreprintMolecular Biology