A deep learning and co-conservation framework enable discovery of non-canonical Cas proteins
Bei‐Bei He, Chen Qi, Yuanyuan Feng, Dong Liu, Rongqian Wu, Zongan Wang, Dandan Wang, Zhen Yue, Yong Zhang, Hongxia Lan, Yue Zheng, Yuxiang Li
The paper introduces BioPrinCRISPR, a framework to identify and characterize CRISPR-Cas systems, revealing non-canonical variants and novel domain architectures across bacterial genomes.
bioRxiv · Sep 30, 2025 · PreprintSynthetic Biology