Yue Zheng

The paper identifies a novel Cas12a variant, BvCas12a, with high specificity and engineers variants with broader PAM compatibility and improved editing efficiency.

The paper introduces BioPrinCRISPR, a framework to identify and characterize CRISPR-Cas systems, revealing non-canonical variants and novel domain architectures across bacterial genomes.

The paper identifies that pathogenic NLR mutations cause PELO-independent ATPase activation, leading to inflammatory responses and disease, and suggests this as a diagnostic marker.

The paper investigates how HIV's transcriptional circuit, which bypasses host regulatory checkpoints, is influenced by host phase fragility, affecting viral latency and reactivation.