Zhengwen Zhang

This study shows that DDI2 deficiency reduces liver cancer growth by increasing ROS and DNA damage, which inhibits cell survival and tumor progression.

The paper investigates the regulatory relationship between Nrf1 and SREBP1, finding that Nrf1 is not a direct target of SREBP1, despite both being part of the rapamycin-responsive network in human hepatoma cells.

This study shows Nrf1 is essential for mitochondrial homeostasis by integrating redox regulatory networks, with loss of Nrf1 leading to increased ROS and oxidative damage.

This study shows that Nrf1 knockout leads to Nrf2 hyperactivation, promoting hepatoma, and reveals a feedback loop between Nrf1 and Nrf2 in tumor suppression.

The paper identifies a novel ancestral subfamily of CNC-bZIP transcription factors, Nach, tracing their evolutionary origin from marine bacteria to humans and showing distinct functional differences from Nrf1/2.