Reziyamu Wufuer

Curcumin activates distinct programming of redox metabolism towards differential regulation of gene expression mediated by Nrf1 and Nrf2

This study investigates how curcumin modulates Nrf1 and Nrf2 expression and their roles in redox metabolism and gene regulation in HepG2 cells and xenograft tumors.

Deletion of Nrf1α promotes glutamine addiction of HepG2 cells and thus enhances its apoptosis caused by glutamine deprivation

This study shows that deleting Nrf1α in HepG2 cells increases glutamine addiction and enhances cell death when glutamine is deprived.

Deficiency of DDI2 suppresses liver cancer progression byworsening cell survival conditions

This study shows that DDI2 deficiency reduces liver cancer growth by increasing ROS and DNA damage, which inhibits cell survival and tumor progression.

Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks

This study shows Nrf1 is essential for mitochondrial homeostasis by integrating redox regulatory networks, with loss of Nrf1 leading to increased ROS and oxidative damage.