Meng Wang

This study shows Nrf1 is essential for mitochondrial homeostasis by integrating redox regulatory networks, with loss of Nrf1 leading to increased ROS and oxidative damage.

This study shows that Nrf1 knockout leads to Nrf2 hyperactivation, promoting hepatoma, and reveals a feedback loop between Nrf1 and Nrf2 in tumor suppression.

The paper identifies a naturally-occurring Keap1 mutant, Keap1{Delta}C, that acts as a dominant-negative competitor, reducing Keap1's ability to inhibit Nrf2 and thereby increasing Nrf2-target gene expression.