A T6SS DNase effector induces nuclear DNA Damage to trigger apoptosis via activation of the cGAS-STING-TNF axis
Song Li, Lei Xu, Pengfei Zhang, Shuying Li, Yichen Qu, Yixin Zhao, Zhenkun Shi, Ruiqi Ma, Yongdong Li, Yi Chen, Yao Wang, Zhengfan Jiang, Gehong Wei, Xihui Shen
This paper identifies TkeA, a T6SS DNase effector from Yersinia pseudotuberculosis, which induces host apoptosis via the cGAS-STING-TNF axis and promotes bacterial competition.
Advanced Science · May 14, 2025Peer-reviewedMicrobiology