Interference with Systemic Negative Feedback Regulation as a Potential Mechanism for Nonmonotonic Dose-Responses of Endocrine-Disrupting Chemicals
Zhenzhen Shi, Shuo Xiao, Qiang Zhang
This paper uses computational modeling to explore how endocrine-disrupting chemicals (EDCs) can produce nonmonotonic dose-response (NMDR) effects through interference with systemic negative feedback regulation.
Toxicological Sciences · Apr 30, 2025Peer-reviewedSystems Biology