Shuo Xiao

This study shows wildfire particulate matter induces hyperandrogenism in mice by activating the aryl hydrocarbon receptor, affecting ovarian function.

This study integrates large language models with adverse outcome pathways to predict developmental neurotoxicity and generate mechanistic explanations, showing improved performance with few-shot prompting.

This paper develops a 3D in vitro model of ovarian follicle-endometrial organoid co-culture that mimics ovarian control of endometrial decidualization, showing similar but distinct transcriptional patterns compared to traditional hormone-based methods.

This study shows that exposure to a mixture of long-chain PFAS disrupts ovarian function in female mice, affecting follicle development, ovulation, and luteal function.

This study identifies PCSK5A and GDF9 as key regulators of cumulus-oocyte-complex matrix integrity and cumulus cell migration during late ovulation, with implications for fertility therapeutics.

An engineered EGFR-targeting DARPin selectively inhibits ovulation through extracellular receptor blockade and establishes a versatile platform for investigating ovarian signaling and reproductive disorders.

This study compares cAMP and EPC-induced decidualization in 3D human endometrial organoids, finding that EPC induces broader and more physiologically relevant transcriptional changes.

This study shows that inhibiting JNK in oocytes protects against chemotherapy-induced infertility and ovarian hormone loss in mice.

This study shows MC-LR accumulates in placental trophoblasts via OATP-mediated transport, with uptake increased under hypoxia and cell fusion.

vToxiNet predicts drug-induced hepatotoxicity using a biologically constrained deep learning framework, achieving robust performance and mechanistic interpretability.

This paper uses computational modeling to explore how endocrine-disrupting chemicals (EDCs) can produce nonmonotonic dose-response (NMDR) effects through interference with systemic negative feedback regulation.

This study investigates the effects of long- and short-chain PFAS on ovarian function in mice, finding that long-chain PFAS disrupt follicle maturation and ovulation via PPARγ activation.

This paper develops a mechanistic model of ovarian follicle depletion and evaluates how chemical exposures affect the biphasic depletion pattern and menopausal timing.

This study investigates the dose-response effects of FSH on mouse folliculogenesis using single-cell RNA sequencing, revealing gene expression patterns and potential molecular mechanisms of FSH-induced ovarian disorders.