Qiang Zhang

This paper develops a 3D in vitro model of ovarian follicle-endometrial organoid co-culture that mimics ovarian control of endometrial decidualization, showing similar but distinct transcriptional patterns compared to traditional hormone-based methods.

This study shows that exposure to a mixture of long-chain PFAS disrupts ovarian function in female mice, affecting follicle development, ovulation, and luteal function.

This study compares cAMP and EPC-induced decidualization in 3D human endometrial organoids, finding that EPC induces broader and more physiologically relevant transcriptional changes.

This study shows that inhibiting JNK in oocytes protects against chemotherapy-induced infertility and ovarian hormone loss in mice.

This paper uses computational modeling to explore how endocrine-disrupting chemicals (EDCs) can produce nonmonotonic dose-response (NMDR) effects through interference with systemic negative feedback regulation.

This study investigates the effects of long- and short-chain PFAS on ovarian function in mice, finding that long-chain PFAS disrupt follicle maturation and ovulation via PPARγ activation.

This study investigates the dose-response effects of FSH on mouse folliculogenesis using single-cell RNA sequencing, revealing gene expression patterns and potential molecular mechanisms of FSH-induced ovarian disorders.

The paper develops a multiscale model of the mammalian liver circadian clock to show that intercellular communication is necessary for sustained circadian oscillations with a near 24-hour period.

The paper models how posttranslational modifications affect protein stability and signal amplification, showing that stabilization can enhance ultrasensitivity and alter response dynamics.

This paper uses mathematical modeling to quantify the signaling properties of the KEAP1-NRF2 system, revealing mechanisms of ultrasensitivity and response dynamics to oxidative stress.