Author

Zhiye Guo

ByteDance (China)Primary ORCID profile (0000-0001-5598-4834 · 12 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Zhiye GuoiD12 papers · University of Missouri

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:simulation· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Junwei CheniD· 2 shared Qilong Wu· 2 shared Yuli She· 2 shared Gaodeng Li· 1 shared Jian ZhangiD· 1 shared Jianzhu MaiD· 1 shared Jiqing ZhengiD· 1 shared Kai Liu· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

Junwei ChenORCID

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2 papers

Recent·Most cited

Programming Biomolecular Interactions with All-Atom Generative Model

Xiangzhe Kong, Junwei Chen, Ziting Zhang, Gaodeng Li, Qingyuan Zhu, L Wei, Mingyu Li, Yan Shi, Weiyang Dai, Zishen Zhang, Wenjuan Tan, Rui Jiao, Xiaolun Wang, Jiqing Zheng, Ziyang Yu, , Jianzhu Ma

This paper introduces AnewOmni, a generative model that designs biomolecules across scales by learning interaction patterns and physical constraints from 5 million complexes.

bioRxiv · Jun 4, 2026 · PreprintBioengineering

Delta PSA: A New Metric for Conformational Dynamics Underlying Macrocyclic Peptide Permeability

Yiping Yu, Qilong Wu, Junwei Chen, Yuli She, Lizhe Zhu, Zhiye Guo

The paper introduces Delta PSA, a metric for predicting macrocyclic peptide permeability using MD simulations, achieving lower MSE than existing methods.

bioRxiv · Jan 6, 2026 · PreprintBiochemistry