Phosphorylation inhibits intramolecular interactions, DNA-binding and protein interactions of Claspin through disordered/ structured conformation transition
Zhiying You, Hao-Wen Hsiao, Chi-Chun Yang, Hidemasa Goto, Hisao Masai
This study shows phosphorylation of Claspin induces a conformational change from disordered to structured, enhancing DNA binding and replication factor interactions while inhibiting helicase activity.
bioRxiv · Jan 8, 2024 · PreprintMolecular Biology