Chi-Chun Yang

The paper shows heat stress induces Claspin phosphorylation, which activates Chk1 through a mechanism involving the ISR pathway and Cdc7 interaction.

This study shows phosphorylation of Claspin induces a conformational change from disordered to structured, enhancing DNA binding and replication factor interactions while inhibiting helicase activity.

The paper shows that various biological stresses activate Chk1, with Claspin dependence varying by cell cycle phase.

This study identifies Claspin's role in growth recovery from serum starvation by activating the PI3K-PDK1-mTOR pathway through interactions with key signaling molecules.