Author

Hao-Wen Hsiao

Tokyo Metropolitan Institute of Medical ScienceORCID 0000-0002-4723-0773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2

Frequent Co-Authors

Chi-Chun YangiD· 2 shared Hisao MasaiiD· 2 shared Hidemasa GotoiD· 1 shared Zhiying You· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersMolecular Biology

Chi-Chun YangORCID

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2 papers

Recent·Most cited

Phosphorylation inhibits intramolecular interactions, DNA-binding and protein interactions of Claspin through disordered/ structured conformation transition

Zhiying You, Hao-Wen Hsiao, Chi-Chun Yang, Hidemasa Goto, Hisao Masai

This study shows phosphorylation of Claspin induces a conformational change from disordered to structured, enhancing DNA binding and replication factor interactions while inhibiting helicase activity.

bioRxiv · Jan 8, 2024 · PreprintMolecular Biology

Claspin-dependent and -independent Chk1 activation by a panel of biological stresses

Hao-Wen Hsiao, Chi-Chun Yang, Hisao Masai

The paper shows that various biological stresses activate Chk1, with Claspin dependence varying by cell cycle phase.

Biomolecules · Jan 7, 2023Peer-reviewedMolecular Biology