Neuronal secretome from bipolar patient-derived neurons alters network function and contains candidate biomarkers for diagnosis and lithium response
Alessia Pietrantonio, Charles-Etienne Castonguay, Daniel L. Rochefort, Camila Tiefensee Ribeiro, Yumin Liu, Malak Abuzgaya, Isabella Pietrantonio, Ziqi Yu, M Guadalupe Alda, Guy Armand Rouleau, Austen J. Milnerwood, Anouar Khayachi
This study identifies biomarkers in the neuronal secretome of bipolar disorder patients that correlate with disease state and lithium response, revealing their impact on neuronal network function.
bioRxiv · May 14, 2026 · PreprintNeuroscience