Austen J. Milnerwood

The paper investigates how LRRK2 activity affects dopamine release in mice, showing age- and sex-dependent changes and rapid reversal with inhibition in certain groups.

The paper examines age and sex-dependent changes in dopamine release in dorsal and ventral striatum of mice, finding increased dorsal striatal release in males during adolescence to young adulthood, linked to behavioral changes.

This study identifies biomarkers in the neuronal secretome of bipolar disorder patients that correlate with disease state and lithium response, revealing their impact on neuronal network function.

This study shows that the LRRK2 G2019S mutation enhances neutrophil effector functions and drives intestinal inflammation in a mouse model of infectious colitis.

This study shows that VPS35(D620N) mutation leads to increased glutamate and dopamine transmission in mice, which can be reversed by LRRK2 inhibition.

This study investigates the role of cathepsin B in Parkinson's disease by analyzing genetic variants and manipulating catB function in cell models to assess its impact on lysosomal activity and alpha-synuclein clearance.

The paper identifies molecular signatures of neuronal hyperexcitability and lithium responsiveness in bipolar disorder neurons, suggesting new therapeutic strategies targeting Akt and AMPK pathways.

The paper shows that inhibiting LRRK2 kinase activity rescues dopamine deficits in VPS35 p.D620N knock-in mice by normalizing DAT function and reducing hyperlocomotion.

This study investigates the effects of the VPS35 D620N mutation on neuronal function, finding increased GluA1 surface expression and altered glutamate transmission, with LRRK2 inhibition affecting GluA1 levels.

This study shows chronic lithium treatment reduces neuronal excitability and shifts the excitatory/inhibitory balance toward inhibition in mouse cortical neurons.

The paper refutes the claim that TMEM230 c.422G>T is a causative mutation for Parkinson disease by showing it is not present in affected family members.