Development of LYTACs via incorporating a nucleolin-targeting and lysosome-directed aptamer
Fang Qiu, Ziting Feng, Hongzhen Chen, Xiaoxuan Zhang, Jianmin Guo, Chunhao Cao, Aiping Lü, Chao Liang
This paper develops LYTACs by conjugating the nucleolin-targeting aptamer SAPT8 with other ligands to enable lysosomal degradation of target proteins in tumors and rheumatoid arthritis fibroblasts.
bioRxiv · Aug 29, 2025 · PreprintPathology