Author

Hongzhen Chen

Southern University of Science and TechnologyORCID 0000-0001-7578-7248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:deep learning· 1

Frequent Co-Authors

Aiping LüiD· 2 shared Fang QiuiD· 2 shared Chao LiangiD· 1 shared Chao LiangiD· 1 shared Chunhao CaoiD· 1 shared Jianmin GuoiD· 1 shared Junyi ZhaoiD· 1 shared Shiding Ying· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPathology

Aiping LüORCID

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2 papers

Recent·Most cited

PathologybioRxivPreprintAug 29, 2025

Development of LYTACs via incorporating a nucleolin-targeting and lysosome-directed aptamer

Fang Qiu, Ziting Feng, Hongzhen Chen…·Chao Liang

This paper develops LYTACs by conjugating the nucleolin-targeting aptamer SAPT8 with other ligands to enable lysosomal degradation of target proteins in tumors and rheumatoid arthritis fibroblasts.

1 citation

humanproteomics

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Cancer BiologybioRxivPreprintJul 22, 2025

Targeting nucleolin facilitates the development of blood-tumor barrier-penetrating and glioblastoma-specific PROTACs

Hongzhen Chen, Junyi Zhao, Fang Qiu…·Chao Liang

This paper develops PROTACs that cross the blood-tumor barrier by targeting nucleolin, showing anti-glioblastoma efficacy without toxicity.

DOI 10.1101/2025.07.22.666084

humanproteomics

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