The functional neuronal lipotype is specified by activity and PS synthesis using dietary and lysosomal inputs
Ryan J Lee, Irma Magaly Rivas‐Serna, Emma K. Theisen, Adriana Bibo, Elizabeth Baird Hardy, Wendy Cheng, Zixiang Zhou, Jocelyn S Chavez-Rios, James C. Forward, Tiffany Pham, Connon I. Thomas, Anza Darehshouri, Vera Christine Mazurak, Michael Thomas Clandinin, John P. Vaughen
The paper identifies n-3 phosphatidylserines as a conserved neuronal lipotype dependent on dietary and lysosomal inputs, showing its role in synaptic function and circuit behavior.
bioRxiv · Oct 1, 2026 · PreprintNeuroscience