Pre-existing levels of pro-survival proteins and induction of BCL-XL dictate cell fate after p53 activation
Allan Shuai Huang, Elizabeth Lieschke, Pedro L. Baldoni, Annabella Thomas, Julia M. Marchingo, Lauren Whelan, Grace Khuu, Eddie La Marca, Michael J. G. Milevskiy, Aisling M. Ross, Timothy M. Johanson, Margaret A. Potts, Leonie Gibson, Vineet Vaibhav, Laura F. Dagley, , Andreas Strasser
The paper shows that pre-existing levels of pro-survival proteins and BCL-XL induction determine cell fate after p53 activation, with implications for cancer therapy.
bioRxiv · Jul 2, 2026 · PreprintCancer Biology