Author

Margaret A. Potts

The University of MelbourneORCID 0000-0001-9796-9683Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Lauren Whelan· 3 shared Andrew J. KuehiD· 2 shared Benjamin HaleyiD· 2 shared Christina KoenigiD· 2 shared Gemma L. KellyiD· 2 shared Jean‐Philippe FortiniD· 2 shared John E. La MarcaiD· 2 shared Kristel M. DorighiiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Lauren Whelan

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

Sarah T. Diepstraten, Yexuan Deng, Margaret A. Potts, Amy J. Heidersbach, Christina Koenig, Kristel M. Dorighi, Lin Tai, Andrew J. Kueh, Lauren Whelan, Catherine W.T. Chang, Felix Brown, Gemma L. Kelly, Jean‐Philippe Fortin, Benjamin Haley, John E. La Marca, Marco J. Herold

This paper introduces Partita, a high-density CRISPRa platform for comprehensive gene activation studies, demonstrating its utility in identifying cancer dependencies and resistance pathways in vitro and in vivo.

Science Advances · Sep 18, 2026Peer-reviewedCancer Biology

Pre-existing levels of pro-survival proteins and induction of BCL-XL dictate cell fate after p53 activation

Allan Shuai Huang, Elizabeth Lieschke, Pedro L. Baldoni, Annabella Thomas, Julia M. Marchingo, Lauren Whelan, Grace Khuu, Eddie La Marca, Michael J. G. Milevskiy, Aisling M. Ross, Timothy M. Johanson, Margaret A. Potts, Leonie Gibson, Vineet Vaibhav, Laura F. Dagley, , Andreas Strasser

The paper shows that pre-existing levels of pro-survival proteins and BCL-XL induction determine cell fate after p53 activation, with implications for cancer therapy.

bioRxiv · Jul 2, 2026 · PreprintCancer Biology

Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening

Wei Jin, Yexuan Deng, John E. La Marca, Emily J. Lelliott, Sarah T. Diepstraten, Christina Koenig, Lin Tai, Valentina Snetkova, Kristel M. Dorighi, Luke Hoberecht, Millicent G. Hedditch, Lauren Whelan, Geraldine Healey, Dan Fayle, Kieran Lau, , Marco J. Herold

The paper introduces an enAsCas12a mouse model and associated libraries for efficient gene editing and screening, identifying drug resistance genes and enabling simultaneous gene knockouts and activations.

Nature Communications · Jan 30, 2025Peer-reviewedMolecular Biology