Spiperone targets HBV cccDNA via ER stress induced innate immune activation and epigenetic silencing
Junghwa Jang, Ziyun Kim, Eunseo Kim, Jisung Park, Yu-Min Choi, Bum‐Joon Kim
This study identifies Spiperone as a repurposed drug that reduces HBV cccDNA through ER stress and epigenetic mechanisms, showing synergistic effects with tenofovir.
bioRxiv · Apr 1, 2026 · PreprintMicrobiology