Hyunsoo Kim

Structural proteomics reveals a coagulation-complement accessibility signature of macrovascular invasion in hepatocellular carcinoma

The paper uses accessibility-based serum proteomics to identify a coagulation-complement signature associated with macrovascular invasion in hepatocellular carcinoma.

A targeted mass-spectrometry plasma proteome for simultaneous multi-disease screening

This paper demonstrates that a targeted plasma proteome measurement can detect multiple diseases with high accuracy, though validation remains needed for clinical use.

Sex and race shape serum protein biomarkers and bias diagnostic reference intervals

The paper quantifies protein biomarkers across diverse demographics and shows sex and race influence reference intervals, leading to potential misclassification.

A targeted plasma-proteomic axis separates autoimmune thyroid disease from growth-hormone deficiency

This study uses targeted plasma proteomics to identify a biomarker axis distinguishing autoimmune thyroid disease from growth-hormone deficiency, but not within-class severity.

Essential Resources for Curated Immune Markers and Antibody Panels in Cytometry Analysis

The paper introduces ImapDB, a database for immune markers and antibody panels, to streamline immune profiling assays and enhance research efficiency.

Age-dependent Structural Reorganization of the Human Plasma Proteome

The paper identifies age-dependent structural changes in the human plasma proteome using Covalent Protein Painting and MRM-LC-MS/MS, revealing patterns that may serve as structural biomarkers.

Biomarker Discovery via Integrative Multi-omics for Children exposed to Humidifier Disinfectant

This study identifies a multi-marker panel with 81.46% accuracy for detecting pulmonary dysfunction in children exposed to humidifier disinfectants using integrative multi-omics analysis.

Proteomic Signatures of Hepatitis B Virus Mutations Reveal Genotype-Specific Host Responses and Biomarker Candidates

The paper uses proteomics to analyze HBV-infected patient serum samples, identifying genotype-specific proteomic signatures and potential biomarkers.

In Silico Design of APOE ε4 Interaction Inhibitor Peptides for Alzheimer's Disease

This paper uses AI to design peptides that inhibit the APOE ε4-APP interaction, showing they bind effectively and disrupt complex formation in simulations.

Integrative Analysis of Proteomics and Metabolomics Reveals Impacts of Sam2 Knockout on Autism Spectrum Disorders

This study uses proteomics and metabolomics to identify molecular changes in Sam2 knockout mice, revealing altered pathways linked to autism spectrum disorder and anxiety.

Elucidating Interactome Dynamics of the A2A Adenosine Receptor

The paper investigates the effects of PDRN on ADORA2A-interacting proteins through proteomic analysis and network modeling, identifying novel interactions and potential sites involved in neuronal differentiation.

In vivo Protein Footprinting Reveals the Dynamic Conformational Changes of Proteome of Multiple Tissues in Progressing Alzheimer's Disease

The paper uses in vivo protein footprinting to study dynamic conformational changes in the proteome across multiple tissues in Alzheimer's disease progression, finding that structural changes precede expression changes in key pathways.

Convergence of distinct subpopulations of mechanosensory neurons onto a neural circuit that elicits grooming

The paper identifies distinct mechanosensory neuron subpopulations in Drosophila that converge onto a shared neural circuit to elicit grooming behavior.