Mechanical cues of extracellular matrix determines tumor innervation
Shu‐Heng Jiang, Shan Zhang, Zhiwei Cai, Minhao Yu, Hui Li, Luju Jiang, Shuqi Cai, Yuheng Zhu, Hao Wang, Ruixue Huo, Xiang Xia, Hong‐Fei Yao, Lei Zhu, Xueli Zhang, Li-Peng Hu, , Zhigang Zhang
This study identifies ECM stiffness as a driver of tumor innervation and shows that targeting integrin β1/YAP1 mechanotransduction reduces TIN in preclinical and clinical settings.
bioRxiv · Mar 25, 2024 · PreprintNeuroscience