Zhigang Zhang

This study shows that tumor-driven remodeling of metastatic lymph nodes involves sympathetic neural rewiring mediated by stromal HGF and mechanical cues.

The paper shows that sympathetic norepinephrine in tumor-draining lymph nodes modifies GZMB in CD8 T cells to enhance cytotoxicity and improve tumor control.

The paper introduces a DNA nanostructure-based platform for single-base RNA mutation detection in living cells, demonstrating its ability to distinguish insulin mRNAs and detect KRASG12D mutations with high specificity.

The paper shows pancreatic islets actively shape sympathetic innervation, with Reg2 and Reg3β promoting nerve regeneration and islet function.

This study identifies ECM stiffness as a driver of tumor innervation and shows that targeting integrin β1/YAP1 mechanotransduction reduces TIN in preclinical and clinical settings.

The paper analyzes miRNA-gene positive correlations across 31 cancers using TCGA data, finding their prevalence, clinical relevance, and potential epigenetic mechanisms.