Xueli Zhang

This study shows citalopram reduces hepatocellular carcinoma by modulating C5aR1+ tumor-associated macrophages and enhancing CD8+ T cell anti-tumor immunity.

The paper develops RFdiffusion to generate protein binders for IDPs/IDRs, achieving nanomolar affinity and functional applications in amylin and IL2RG.

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

This study identifies ECM stiffness as a driver of tumor innervation and shows that targeting integrin β1/YAP1 mechanotransduction reduces TIN in preclinical and clinical settings.