The Activation of MEK1 by Enhanced Homodimerization Drives Tumorigenesis
Jimin Yuan, Wan Hwa Ng, Zizi Tian, Jiajun Yap, Manuela Baccarini, Zhongzhou Chen, Jiancheng Hu
This study identifies MEK mutants that drive tumorigenesis through enhanced homodimerization and cross-phosphorylation, highlighting implications for therapy design.
bioRxiv · Dec 6, 2017 · PreprintCancer Biology