Fibro-Adipogenic Progenitors require autocrine IGF-I in homeostatic and regenerating skeletal muscle
Yangyi E. Luo, Zoe Abe-Teh, Tarek Y. Alsaghir, Li-Ying Kuo, Fahong Yu, Bradley E. Stoker, Yumei Zhou, Ambili Bai Appu, Elijah M. Dy, Feng Yue, Daniel Kopinke, Elisabeth R. Barton
This study shows that autocrine IGF-I is essential for FAP function in muscle homeostasis and regeneration, with loss of IGF-I leading to impaired regeneration and altered FAP properties.
Stem Cell Reports · Jun 25, 2026Peer-reviewedMolecular Biology