Ambili Bai Appu

This study shows that autocrine IGF-I is essential for FAP function in muscle homeostasis and regeneration, with loss of IGF-I leading to impaired regeneration and altered FAP properties.

This study shows that primary cilia in cardiac fibroblasts promote fibrosis and impair heart function after myocardial infarction by amplifying fibrotic signaling.

This study shows that intramuscular adipose tissue (IMAT) accumulation worsens limb function in PAD/CLTI, and reducing IMAT improves muscle strength and work output in mice.

This study shows that blocking intramuscular adipose tissue (IMAT) formation after muscle injury improves muscle regeneration and function in mice.

This study identifies DHH as a key ligand in the Hedgehog signaling pathway that regulates fibro/adipogenic progenitor fate during skeletal muscle regeneration, preventing adipogenesis and promoting fibrosis.