Blm10/PA200-activated 20S proteasomes promote α-synuclein degradation and bypass proteasome inhibition in Parkinson disease models
Tariq Tammam Ali, Anton Zhornyak, Madiha Mohieldin Merghani, Zora Buschenlange, Eri Sakata, Tiago F. Outeiro, Bilyana Popova, Gerhard H. Braus
This study shows that Blm10/PA200 activates 20S proteasomes to degrade α-synuclein and resist inhibition, improving proteostasis in Parkinson's disease models.
Aging Cell · May 28, 2026Peer-reviewedCell Biology