CryoDDM: CryoEM denoising diffusion model for heterogeneous conformational reconstruction
Fuwei Li, Yuanbo Chen, Hao Dong, Chenxuan Ji, Xinsheng Wang, Chuanyang Zhang, Zupeng Wang, Bin Xiang Hu, Fa Zhang, Xiaohua Wan
CryoDDM improves cryo-EM reconstruction by denoising images to capture conformational heterogeneity, validated on proteasome, membrane protein, and spike protein datasets.
bioRxiv · Dec 12, 2025 · PreprintBioinformatics