Gizem Gokce Alpkilic

This paper describes a scalable recombinant pipeline for producing disulphide-stapled cyclic peptides, achieving high yields and enabling high-throughput screening.

The paper designs high-affinity miniprotein binders targeting Flpp3, a virulence factor of Francisella tularensis, using physics-based and deep-learning methods, achieving sub-nanomolar affinities.