Karl Landheer

This study benchmarks how different anatomical segmentation tools affect MRS-derived metabolite concentration estimates in brain imaging.

This paper examines how proxy measurements in magnetic resonance spectroscopy affect statistical test outcomes, showing inflated false positive and negative rates due to bias and correlation with gold-standard measurements.

This study quantifies cancer risk and penetrance in CHEK2 heterozygotes using genomic data from two large biobanks, finding increased risks for several cancers and younger age of onset.

This paper introduces multiparametric diffusion MR spectroscopy to estimate cell-type-specific morphology in the human brain by combining diffusion-time-dependent encoding with double-diffusion-encoded spectroscopy.

The paper performs metabolomics exome and genome-wide association studies in Amish adults, identifying genetic variants linked to metabolites and cardiometabolic traits.