Developmental BiologyDevelopmental CellPeer-reviewed
Differential compartmentalization of BMP4/NOGGIN requires NOGGIN trans-epithelial transport
Tien Phan-Everson, Fred Etoc, Shu Li…·Eric D. Siggia
The paper shows that NOGGIN and BMP4 are secreted into opposite extracellular spaces in human epiblasts, with NOGGIN inhibiting BMP4 through apical-to-basal transcytosis.
22 citations