Shu Li

This study reveals how tension-induced structural changes in PIEZO2 channels lead to pore opening and ion conduction through dynamic conformational motions.

This study shows that B cell c-Maf signaling promotes tumor progression in pancreatic cancer and melanoma by modulating Breg, inflammatory responses, and tumor-specific antibody production.

This study shows that HTT-CAG expansion in human gastruloids causes ectodermal compartment reduction and altered TGFβ signaling due to polarity defects, indicating early developmental HD effects.

The paper shows that NOGGIN and BMP4 are secreted into opposite extracellular spaces in human epiblasts, with NOGGIN inhibiting BMP4 through apical-to-basal transcytosis.

The paper shows that WNT signaling memory enables ACTIVIN to act as a morphogen in human gastruloids by allowing graded responses to ACTIVIN without altering SMAD2 dynamics.