Ling-shiang F. Chuang

This study shows GM-CSF reduces intestinal inflammation in Crohn's disease by modulating myeloid cell signaling and ILC-like transcriptional states.

This study investigates how stem cell transplantation (SCT) restores immune function in refractory Crohn's disease by analyzing immune cell remodeling and HSC heterogeneity using single-cell RNA sequencing and functional assays.

The paper uses measured and predicted gene expression to identify ulcerative colitis patients at elevated risk of colectomy, showing both methods independently replicate in multiple datasets.